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Inhibition of cholinesterases following percutaneous intoxication with V agents in rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50015587" target="_blank" >RIV/62690094:18470/19:50015587 - isvavai.cz</a>

  • Alternative codes found

    RIV/60162694:G44__/21:00557157

  • Result on the web

    <a href="https://www.tandfonline.com/doi/abs/10.1080/15569543.2018.1564773?journalCode=itxr20" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/15569543.2018.1564773?journalCode=itxr20</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/15569543.2018.1564773" target="_blank" >10.1080/15569543.2018.1564773</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Inhibition of cholinesterases following percutaneous intoxication with V agents in rats

  • Original language description

    Female Wistar rats were percutaneously (p.c.) intoxicated (1xLD(50)) with VX and its two derivatives differing in their substitution on nitrogen (diethyl- and dibutyl- derivatives). Blood cholinesterase activity was continuously monitored; 100 min after the intoxication (or after death), acetylcholinesterase (AChE) activity was determined in diaphragm and brain parts (pontomedullar area - PM, frontal cortex - FC, and basal ganglia - BG). Blood ChE activity remains unchanged at very short interval (5 min) after VX administration; this interval was prolonged for diethyl- and dibutyl derivatives. AChE activity was decreased to 20-30% of control values in diaphragm, then in FC (60-70%) and PM (54-74%). AChE activity in BG was relatively resistant (cca 80%). When the AChE activity was compared for all three agents in relationship to survival (11 animals) or death (7 animals), significant differences between the activities in survived (32%) and died (13%) rats were demonstrated in diaphragm but not in the blood. This tendency (higher AChE activity in survived animals) was also observed in PM and FC, however, not statistically significant. It is concluded that both parts of the molecule - substitution on nitrogen atom and the rest of agent molecule (phosphorus head) probably influence penetration through the skin and simultaneously AChE inhibition. As hypothesis, AChE activity in diaphragm could be important for survival or death in case of acute p.c. intoxication with these types of V agents.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30108 - Toxicology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    TOXIN REVIEWS

  • ISSN

    1556-9543

  • e-ISSN

  • Volume of the periodical

    Neuveden

  • Issue of the periodical within the volume

    April

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    1-6

  • UT code for WoS article

    000470517100001

  • EID of the result in the Scopus database

    2-s2.0-85065411147