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Activation of protein kinase C suppresses fragmentation of pig oocytes aged in vitro

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F11%3A50748" target="_blank" >RIV/60460709:41210/11:50748 - isvavai.cz</a>

  • Alternative codes found

    RIV/00027014:_____/11:#0001389

  • Result on the web

    <a href="http://dx.doi.org/10.1017/S1751731110002119" target="_blank" >http://dx.doi.org/10.1017/S1751731110002119</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1017/S1751731110002119" target="_blank" >10.1017/S1751731110002119</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Activation of protein kinase C suppresses fragmentation of pig oocytes aged in vitro

  • Original language description

    When cultured for an extended time, pig oocytes which matured in vitro to the stage of metaphase II undergo the complex process designated as ageing. Activation of protein kinases C (PKCs) using phorbol-12-myristate-13-acetate (PMA) protects oocytes fromfragmentation. None oocyte was fragmented after 3 days of ageing in 50 nM of PMA. A similar effect (8 % of fragmented oocytes) was observed after 3 day treatment of ageing oocytes with 100 ?M of 1-stearoyl-2arachidonoyl-sn-glycerol (STEAR). PMA and STEAR activate both calcium-dependent and calcium-independent PKCs. This combined effect on PKCs seems to be essential for the protection of oocytes from fragmentation. Neither the specific activator of calcium-dependent PKCs 1-oleoyl-2-acetyl-sn-glycerol (OLE) nor specific activator of calcium-independent PKCs dipalmitoyl-L-alpha-phosphatidylinositol-3,4,5-triphosphate heptaammonium salt (DIPALM) suppressed fragmentation of ageing pig oocytes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    GG - Zootechnics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/QG50052" target="_blank" >QG50052: Reproductive biotechniques in pigs</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Animal

  • ISSN

    1751-7311

  • e-ISSN

  • Volume of the periodical

    5

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    565-571

  • UT code for WoS article

    000288130800009

  • EID of the result in the Scopus database