LC-ESI-MS-MS Method for Monitoring Dopamine, Serotonin and Their Metabolites in Brain Tissue
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F11%3A43892006" target="_blank" >RIV/60461373:22310/11:43892006 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/11:00364479 RIV/00023752:_____/11:00001181 RIV/00216208:11120/11:00003214
Result on the web
<a href="http://dx.doi.org/10.1007/s10337-011-1959-9" target="_blank" >http://dx.doi.org/10.1007/s10337-011-1959-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10337-011-1959-9" target="_blank" >10.1007/s10337-011-1959-9</a>
Alternative languages
Result language
angličtina
Original language name
LC-ESI-MS-MS Method for Monitoring Dopamine, Serotonin and Their Metabolites in Brain Tissue
Original language description
A rapid and precise LC-ESI-MS-MS method for the parallel identification and quantification of dopamine, serotonin and their metabolites (homovanillic acid, 3-methoxytyramine, 3,4-dihydroxyphenylacetic acid and 5-hydroxyindolacetic acid) from rat brain tissue without any pre-analysis adjustment of the sample such as pre-concentration or derivatization has been developed. In particular, the reaction-monitoring mode was selected for its extremely high degree of selectivity and the stable-isotope-dilution assay for its high precision of quantification. Alternation the ionization polarity in the course of mass spectrometry detection enabled to determine substances susceptible to various ionization modes in only one analysis run. This fact, in combination with an easy pre-treatment step, constitutes the method straightforward and time undemanding. The developed method was characterized with a high precision (?19.5%, determined as RSD), an acceptable accuracy (?82.0%, determined as recovery),
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chromatographia
ISSN
0009-5893
e-ISSN
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Volume of the periodical
73
Issue of the periodical within the volume
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Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
143-149
UT code for WoS article
000290804900017
EID of the result in the Scopus database
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