A Study on the Intramolecular Mitsunobu Reaction of N6-(?-hydroxyalkyl)adenines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F17%3A43915022" target="_blank" >RIV/60461373:22310/17:43915022 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/jhet.2982/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jhet.2982/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jhet.2982" target="_blank" >10.1002/jhet.2982</a>

Result language
angličtina
Original language name
A Study on the Intramolecular Mitsunobu Reaction of N6-(?-hydroxyalkyl)adenines
Original language description
The cyclization of N6-(?-hydroxyalkyl)adenines with a N6H-group leads to N6,N1 ring closure regardless of the method of the cyclization that was used. Five-membered to eight-membered rings were obtained using NBS/PPh3; however, under Mitsunobu conditions, the eight-membered fused purine was not formed. Surprisingly, the cyclization of N6-methyl-N6-(4-hydroxybutyl)adenine only leads to N6,N7 ring closure using both methods
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GA203%2F09%2F1552" target="_blank" >GA203/09/1552: Application of 7,8-Dihydropurines in the Synthesis of New Purine Derivatives with Potential Biological Activity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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