Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922073" target="_blank" >RIV/60461373:22330/21:43922073 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22340/21:43922073 RIV/60461373:22810/21:43922073 RIV/67985858:_____/21:00559341

Result on the web

<a href="https://www.mdpi.com/1999-4923/13/3/412/htm" target="_blank" >https://www.mdpi.com/1999-4923/13/3/412/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/pharmaceutics13030412" target="_blank" >10.3390/pharmaceutics13030412</a>

Result language

angličtina

Original language name

Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution

Original language description

Stability studies represent an essential component of pharmaceutical development, enabling critical evaluation of the therapeutic potential of an active pharmaceutical ingredient (API) or a final pharmaceutical product under the influence of various environmental factors. The aim of the present study was to investigate the chemical stability of cannabidiol (CBD) in the form of a solid powder (hereinafter referred to as CBD powder) and also dissolved in sunflower oil. We performed stress studies in accordance with the International Conference on Harmonization (ICH) guidelines, where 5 mg of marketed CBD in the form of a solid powder and in form of oil solution were exposed for 7 and 14, 30, 60, 90, 180, 270, and 365 days to precisely defined temperature and humidity conditions, 25 degrees C +/- 2 degrees C/60% RH +/- 5% and 40 degrees C +/- 2 degrees C/75% RH +/- 5% in both open and closed vials in the dark. CBD powder was significantly more stable than CBD in oil solution. Such finding is important because CBD is often administered dissolved in oil matrix in practice due to very good bioavailability. Thus, the knowledge on admissible shelf time is of paramount importance.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

<a href="/en/project/VI20172020056" target="_blank" >VI20172020056: New synthetics drugs - complex interdisciplinary research centre</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PHARMACEUTICS

ISSN

1999-4923

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

412

UT code for WoS article

000634052400001

EID of the result in the Scopus database

2-s2.0-85103095414