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Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F21%3A00559341" target="_blank" >RIV/67985858:_____/21:00559341 - isvavai.cz</a>

  • Alternative codes found

    RIV/60461373:22330/21:43922073 RIV/60461373:22340/21:43922073 RIV/60461373:22810/21:43922073

  • Result on the web

    <a href="https://www.mdpi.com/1999-4923/13/3/412" target="_blank" >https://www.mdpi.com/1999-4923/13/3/412</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/pharmaceutics13030412" target="_blank" >10.3390/pharmaceutics13030412</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution.

  • Original language description

    Stability studies represent an essential component of pharmaceutical development, enabling critical evaluation of the therapeutic potential of an active pharmaceutical ingredient (API) or a final pharmaceutical product under the influence of various environmental factors. The aim of the present study was to investigate the chemical stability of cannabidiol (CBD) in the form of a solid powder (hereinafter referred to as CBD powder) and also dissolved in sunflower oil. We performed stress studies in accordance with the International Conference on Harmonization (ICH) guidelines, where 5 mg of marketed CBD in the form of a solid powder and in form of oil solution were exposed for 7 and 14, 30, 60, 90, 180, 270, and 365 days to precisely defined temperature and humidity conditions, 25 ◦C ± 2 ◦C/60% RH ± 5% and 40 ◦C ± 2 ◦C/75% RH ± 5% in both open and closed vials in the dark. CBD powder was significantly more stable than CBD in oil solution. Such finding is important because CBD is often administered dissolved in oil matrix in practice due tonvery good bioavailability. Thus, the knowledge on admissible shelf time is of paramount importance.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    20401 - Chemical engineering (plants, products)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pharmaceutics

  • ISSN

    1999-4923

  • e-ISSN

    1999-4923

  • Volume of the periodical

    13

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    10

  • Pages from-to

    412

  • UT code for WoS article

    000634052400001

  • EID of the result in the Scopus database

    2-s2.0-85103095414