Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F21%3A00559341" target="_blank" >RIV/67985858:_____/21:00559341 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/21:43922073 RIV/60461373:22340/21:43922073 RIV/60461373:22810/21:43922073
Result on the web
<a href="https://www.mdpi.com/1999-4923/13/3/412" target="_blank" >https://www.mdpi.com/1999-4923/13/3/412</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/pharmaceutics13030412" target="_blank" >10.3390/pharmaceutics13030412</a>
Alternative languages
Result language
angličtina
Original language name
Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution.
Original language description
Stability studies represent an essential component of pharmaceutical development, enabling critical evaluation of the therapeutic potential of an active pharmaceutical ingredient (API) or a final pharmaceutical product under the influence of various environmental factors. The aim of the present study was to investigate the chemical stability of cannabidiol (CBD) in the form of a solid powder (hereinafter referred to as CBD powder) and also dissolved in sunflower oil. We performed stress studies in accordance with the International Conference on Harmonization (ICH) guidelines, where 5 mg of marketed CBD in the form of a solid powder and in form of oil solution were exposed for 7 and 14, 30, 60, 90, 180, 270, and 365 days to precisely defined temperature and humidity conditions, 25 ◦C ± 2 ◦C/60% RH ± 5% and 40 ◦C ± 2 ◦C/75% RH ± 5% in both open and closed vials in the dark. CBD powder was significantly more stable than CBD in oil solution. Such finding is important because CBD is often administered dissolved in oil matrix in practice due tonvery good bioavailability. Thus, the knowledge on admissible shelf time is of paramount importance.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20401 - Chemical engineering (plants, products)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutics
ISSN
1999-4923
e-ISSN
1999-4923
Volume of the periodical
13
Issue of the periodical within the volume
3
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
412
UT code for WoS article
000634052400001
EID of the result in the Scopus database
2-s2.0-85103095414