Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F22%3A43925354" target="_blank" >RIV/60461373:22330/22:43925354 - isvavai.cz</a>
Result on the web
<a href="http://file:///C:/Users/landovam/Downloads/ijms-23-15121-v2-1.pdf" target="_blank" >http://file:///C:/Users/landovam/Downloads/ijms-23-15121-v2-1.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms232315121" target="_blank" >10.3390/ijms232315121</a>

Result language
angličtina
Original language name
Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity
Original language description
A library of previously unknown halogenated derivatives of flavonolignans (silybins A and B, 2,3-dehydrosilybin, silychristin A, and 2,3-dehydrosilychristin A) was prepared. The effect of halogenation on the biological activity of flavonolignans was investigated. Halogenated derivatives had a significant effect on bacteria. All prepared derivatives inhibited the AI-2 type of bacterial communication (quorum sensing) at concentrations below 10 µM. All prepared compounds also inhibited the adhesion of bacteria (Staphyloccocus aureus and Pseudomonas aeruginosa) to the surface, preventing biofilm formation. These two effects indicate that the halogenated derivatives are promising antibacterial agents. Moreover, these derivatives acted synergistically with antibiotics and reduced the viability of antibiotic-resistant S. aureus. Some flavonolignans were able to reverse the resistant phenotype to a sensitive one, implying that they modulate antibiotic resistance. © 2022 by the authors.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/GA21-00551S" target="_blank" >GA21-00551S: Metabolites and selected derivatives of food flavonoids - preparation and biological activity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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