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Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00566377" target="_blank" >RIV/61388963:_____/22:00566377 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388971:_____/22:00566377

  • Result on the web

    <a href="https://www.mdpi.com/1422-0067/23/23/15121" target="_blank" >https://www.mdpi.com/1422-0067/23/23/15121</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/ijms232315121" target="_blank" >10.3390/ijms232315121</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity

  • Original language description

    A library of previously unknown halogenated derivatives of flavonolignans (silybins A and B, 2,3-dehydrosilybin, silychristin A, and 2,3-dehydrosilychristin A) was prepared. The effect of halogenation on the biological activity of flavonolignans was investigated. Halogenated derivatives had a significant effect on bacteria. All prepared derivatives inhibited the AI-2 type of bacterial communication (quorum sensing) at concentrations below 10 µM. All prepared compounds also inhibited the adhesion of bacteria (Staphyloccocus aureus and Pseudomonas aeruginosa) to the surface, preventing biofilm formation. These two effects indicate that the halogenated derivatives are promising antibacterial agents. Moreover, these derivatives acted synergistically with antibiotics and reduced the viability of antibiotic-resistant S. aureus. Some flavonolignans were able to reverse the resistant phenotype to a sensitive one, implying that they modulate antibiotic resistance.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Molecular Sciences

  • ISSN

    1422-0067

  • e-ISSN

    1422-0067

  • Volume of the periodical

    23

  • Issue of the periodical within the volume

    23

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    18

  • Pages from-to

    15121

  • UT code for WoS article

    000897443500001

  • EID of the result in the Scopus database

    2-s2.0-85143809536