Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00566377" target="_blank" >RIV/61388963:_____/22:00566377 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/22:00566377
Result on the web
<a href="https://www.mdpi.com/1422-0067/23/23/15121" target="_blank" >https://www.mdpi.com/1422-0067/23/23/15121</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms232315121" target="_blank" >10.3390/ijms232315121</a>
Alternative languages
Result language
angličtina
Original language name
Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity
Original language description
A library of previously unknown halogenated derivatives of flavonolignans (silybins A and B, 2,3-dehydrosilybin, silychristin A, and 2,3-dehydrosilychristin A) was prepared. The effect of halogenation on the biological activity of flavonolignans was investigated. Halogenated derivatives had a significant effect on bacteria. All prepared derivatives inhibited the AI-2 type of bacterial communication (quorum sensing) at concentrations below 10 µM. All prepared compounds also inhibited the adhesion of bacteria (Staphyloccocus aureus and Pseudomonas aeruginosa) to the surface, preventing biofilm formation. These two effects indicate that the halogenated derivatives are promising antibacterial agents. Moreover, these derivatives acted synergistically with antibiotics and reduced the viability of antibiotic-resistant S. aureus. Some flavonolignans were able to reverse the resistant phenotype to a sensitive one, implying that they modulate antibiotic resistance.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
23
Issue of the periodical within the volume
23
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
15121
UT code for WoS article
000897443500001
EID of the result in the Scopus database
2-s2.0-85143809536