Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893432" target="_blank" >RIV/60461373:22340/12:43893432 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/12:43871090 RIV/61388980:_____/12:00434359

Result on the web

<a href="http://dx.doi.org/10.3390/molecules171113221" target="_blank" >http://dx.doi.org/10.3390/molecules171113221</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules171113221" target="_blank" >10.3390/molecules171113221</a>

Result language

angličtina

Original language name

Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation

Original language description

The solubility, absorption and distribution of a drug are involved in the basic aspects of oral bioavailability Solubility is an essential characteristic and influences the efficiency of the drug. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing oral bioavaibility is the technique of nanoparticle preparation, which allows many drugs to thus reach the intended site of action. Candesartan cilexetil and atorvastatin, belonging toclass II of the biopharmaceutical classification system, were chosen as model active pharmaceutical ingredients in this study. Forty samples were prepared either by antisolvent precipitation/solvent evaporation method or by the emulsion/solvent evaporation technique with various commonly used surface-active excipients as nanoparticle stabilizers. All samples were analyzed by means of dynamic light scattering. The particle size of the determined 36 nanoparticle samples was to 574 nm, whe

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/GAP304%2F11%2F2246" target="_blank" >GAP304/11/2246: Nanotechnology Approaches for Drug Delivery Across Blood-Tissue Barriers</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

13221-13234

UT code for WoS article

000311428400057

EID of the result in the Scopus database

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