Molecular structure study of a heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin complex of cholesterol

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F20%3A43918517" target="_blank" >RIV/60461373:22340/20:43918517 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0039128X19302454?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0039128X19302454?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2019.108555" target="_blank" >10.1016/j.steroids.2019.108555</a>

Result language
angličtina
Original language name
Molecular structure study of a heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin complex of cholesterol
Original language description
Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (2) and cholesterol form a water-soluble complex 3. We performed several NMR studies, particularly 1H, 13C, 2D NOESY and DOSY, at various temperatures on 500 and 950 MHz instruments. We discovered that the complex 3 is unstable above 57 °C in heavy water, while it is kinetically stable enough to be studied by NMR in detail at 1 °C. We demonstrated the formation of a face-to-face 2:1 complex with a binding constant of approximately 2.2 × 106 M−2.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
<a href="/en/project/GA17-02836S" target="_blank" >GA17-02836S: Development of fluorescent probes for determination of content, localization and trafficking of cholesterol within eukaryotic cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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