Impact of crystallization conditions and filtration cake washing on the clustering of metformin hydrochloride crystals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43925024" target="_blank" >RIV/60461373:22340/22:43925024 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21110/22:00359037
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0032591022004168?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0032591022004168?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.powtec.2022.117522" target="_blank" >10.1016/j.powtec.2022.117522</a>
Alternative languages
Result language
angličtina
Original language name
Impact of crystallization conditions and filtration cake washing on the clustering of metformin hydrochloride crystals
Original language description
Crystallization is one of the basic methods employed in the pharmaceutical and chemical industry to produce powder products with controlled purity. Crystallization is commonly associated with the filtration and drying of solid material, where these unit operations can significantly affect the properties of the final material. This study focuses on the interplay of crystallization, filtration, cake washing, and drying to prevent the formation of crystal clusters. In this work, metformin hydrochloride crystalizing in rod-like crystals is used as a model drug. First, the crystallization parameters, such as stirring speed, cooling rate, impeller type, and solvent type, were varied. It was found that in all cases, metformin hydrochloride crystalizes in single rod-like crystals with various crystal size distribution, where the cooling rate and solvent type lead to non-uniform crystal growth demonstrated by very polydisperse crystal size distribution. Experimental results and Computational Fluid Dynamics simulation confirmed that stresses during crystallization were not sufficient to cause significant crystal breakup. In the next step, filtration connected with filter cake washing and subsequent drying was used to study the formation of crystal clusters. It was found that crystal cake was significantly stronger for the non-washed samples than for washed cake. Both the measured apparent elasticity modulus and the apparent hardness confirmed a strong impact of the washing solvent, allowing quality control when developing a crystal production process.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20401 - Chemical engineering (plants, products)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Powder Technology
ISSN
0032-5910
e-ISSN
1873-328X
Volume of the periodical
405
Issue of the periodical within the volume
JUN 2022
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
117522
UT code for WoS article
000809770800006
EID of the result in the Scopus database
2-s2.0-85130574864