Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne Azide 1,3-Dipolar Cycloaddition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00492075" target="_blank" >RIV/61388963:_____/18:00492075 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/18:10378058
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.orglett.8b01533" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.orglett.8b01533</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.orglett.8b01533" target="_blank" >10.1021/acs.orglett.8b01533</a>
Alternative languages
Result language
angličtina
Original language name
Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne Azide 1,3-Dipolar Cycloaddition
Original language description
Two alternative flexible alkyne-linked thymine nucleosides (propargyl-diethylene glycol- or undecyn-linked 5-hydroxymethyluracil derivatives), as well as their phosphoramidites and triphosphates, were designed and synthesized. The nucleoside 3'-O-phosphoramidites were successfully incorporated into oligonucleotides on a solid support, whereas the nucleoside triphosphates served as good substrates for polymerase synthesis of modified DNA, which underwent fast and efficient copper-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) reactions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Organic Letters
ISSN
1523-7060
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
3962-3965
UT code for WoS article
000438469500056
EID of the result in the Scopus database
2-s2.0-85049664523