Supernova: A Deoxyribozyme that Catalyzes a Chemiluminescent Reaction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00551188" target="_blank" >RIV/61388963:_____/22:00551188 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10457215
Result on the web
<a href="https://doi.org/10.1002/anie.202109347" target="_blank" >https://doi.org/10.1002/anie.202109347</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.202109347" target="_blank" >10.1002/anie.202109347</a>
Alternative languages
Result language
angličtina
Original language name
Supernova: A Deoxyribozyme that Catalyzes a Chemiluminescent Reaction
Original language description
Functional DNA molecules are useful components in nanotechnology and synthetic biology. To expand the toolkit of functional DNA parts, in this study we used artificial evolution to identify a glowing deoxyribozyme called Supernova. This deoxyribozyme transfers a phosphate from a 1,2-dioxetane substrate to its 5′ hydroxyl group, which triggers a chemiluminescent reaction and a flash of blue light. An engineered version of Supernova is only catalytically active in the presence of an oligonucleotide complementary to its 3′ end, demonstrating that light production can be coupled to ligand binding. We anticipate that Supernova will be useful in a wide variety of applications, including as a signaling component in allosterically regulated sensors and in logic gates of molecular computers.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Angewandte Chemie - International Edition
ISSN
1433-7851
e-ISSN
1521-3773
Volume of the periodical
61
Issue of the periodical within the volume
3
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
e202109347
UT code for WoS article
000722279100001
EID of the result in the Scopus database
2-s2.0-85120631774