Neurosteroids as positive and negative allosteric modulators of ligand-gated ion channels: P2X receptor perspective

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00572394" target="_blank" >RIV/61388963:_____/23:00572394 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/23:00572394 RIV/00216208:11310/23:10480008

Result on the web

<a href="https://doi.org/10.1016/j.neuropharm.2023.109542" target="_blank" >https://doi.org/10.1016/j.neuropharm.2023.109542</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neuropharm.2023.109542" target="_blank" >10.1016/j.neuropharm.2023.109542</a>

Result language

angličtina

Original language name

Neurosteroids as positive and negative allosteric modulators of ligand-gated ion channels: P2X receptor perspective

Original language description

Neurosteroids are steroids synthesized de novo in the brain from cholesterol in an independent manner from peripheral steroid sources. The term “neuroactive steroid“ includes all steroids independent of their origin, and newly synthesized analogs of neurosteroids that modify neuronal activities. In vivo application of neuroactive steroids induces potent anxiolytic, antidepressant, anticonvulsant, sedative, analgesic and amnesic effects, mainly through interaction with the γ-aminobutyric acid type-A receptor (GABAAR). However, neuroactive steroids also act as positive or negative allosteric regulators on several ligand-gated channels including N-methyl-d-aspartate receptors (NMDARs), nicotinic acetylcholine receptors (nAChRs) and ATP-gated purinergic P2X receptors. Seven different P2X subunits (P2X1-7) can assemble to form homotrimeric or heterotrimeric ion channels permeable for monovalent cations and calcium. Among them, P2X2, P2X4, and P2X7 are the most abundant within the brain and can be regulated by neurosteroids. Transmembrane domains are necessary for neurosteroid binding, however, no generic motif of amino acids can accurately predict the neurosteroid binding site for any of the ligand-gated ion channels including P2X. Here, we will review what is currently known about the modulation of rat and human P2X by neuroactive steroids and the possible structural determinants underlying neurosteroid-induced potentiation and inhibition of the P2X2 and P2X4 receptors.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

<a href="/en/project/LQ1604" target="_blank" >LQ1604: BIOCEV: from Fundamental to Applied Research</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropharmacology

ISSN

0028-3908

e-ISSN

1873-7064

Volume of the periodical

234

Issue of the periodical within the volume

Aug 15

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

109542

UT code for WoS article

000984666300001

EID of the result in the Scopus database

2-s2.0-85152443752