Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F06%3A00040375" target="_blank" >RIV/61388971:_____/06:00040375 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria
Original language description
In the present study, we used for mice immunization recombinant detoxified ACT containing an epitope of Plasmodium berghei CSP. This induced a high number of IFN-gamma-secreting CD8+ T cells, while no protective immunity was achieved. In contrast, when anti-CTLA-4 was administered during boost immunization, complete protection against challenge with P. berghei ANKA (ANtwerpKAtango) sporozoites was induced in a number of mice
Czech name
Imunizace adenylát cyklázovým toxinem Bordetella pertussis nesoucím epitop CSP spolu s blokací CTLA-4 receptoru zajištuje protekci proti malárii působené Plasmodium berghei
Czech description
V této práci jsme pro imunizaci myší použili ACT toxoid, který obsahoval epitop CSP Plasmodium berhei. To vedlo k indukci velkého počtu IFN-gamma-sekretujících CD8+ T buněk, ale nedošlo k vytvoření protektivní imunity. Avšak, pokud byla podána anti CTLA-4 protilátka během boost imunizace, bylo v myších dosaženo ochrany proti letální dávce sporozoitů P. berghei ANKA (ANtwerpKAtango)
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IBS5020311" target="_blank" >IBS5020311: Vaccines for induction of mucosal and systemic immunity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Infection and Immunity
ISSN
0019-9567
e-ISSN
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Volume of the periodical
74
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
2277-2285
UT code for WoS article
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EID of the result in the Scopus database
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