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Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F06%3A00040375" target="_blank" >RIV/61388971:_____/06:00040375 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria

  • Original language description

    In the present study, we used for mice immunization recombinant detoxified ACT containing an epitope of Plasmodium berghei CSP. This induced a high number of IFN-gamma-secreting CD8+ T cells, while no protective immunity was achieved. In contrast, when anti-CTLA-4 was administered during boost immunization, complete protection against challenge with P. berghei ANKA (ANtwerpKAtango) sporozoites was induced in a number of mice

  • Czech name

    Imunizace adenylát cyklázovým toxinem Bordetella pertussis nesoucím epitop CSP spolu s blokací CTLA-4 receptoru zajištuje protekci proti malárii působené Plasmodium berghei

  • Czech description

    V této práci jsme pro imunizaci myší použili ACT toxoid, který obsahoval epitop CSP Plasmodium berhei. To vedlo k indukci velkého počtu IFN-gamma-sekretujících CD8+ T buněk, ale nedošlo k vytvoření protektivní imunity. Avšak, pokud byla podána anti CTLA-4 protilátka během boost imunizace, bylo v myších dosaženo ochrany proti letální dávce sporozoitů P. berghei ANKA (ANtwerpKAtango)

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/IBS5020311" target="_blank" >IBS5020311: Vaccines for induction of mucosal and systemic immunity</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Infection and Immunity

  • ISSN

    0019-9567

  • e-ISSN

  • Volume of the periodical

    74

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    2277-2285

  • UT code for WoS article

  • EID of the result in the Scopus database