Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00422913" target="_blank" >RIV/61388971:_____/13:00422913 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/eji.201142262" target="_blank" >http://dx.doi.org/10.1002/eji.201142262</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/eji.201142262" target="_blank" >10.1002/eji.201142262</a>

Result language

angličtina

Original language name

Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells

Original language description

Protection against malaria can be achieved by induction of a strong CD8+ T-cell response against the Plasmodium circumsporozoite protein (CSP), but most subunit vaccines suffer from insufficient memory responses. In the present study, we analyzed the impact of postimmunization sporozoite challenge on the development of long-lasting immunity. BALB/c mice were immunized by a heterologous prime/boost regimen against Plasmodium berghei CSP that induces a strong CD8+ T-cell response and sterile protection, which is short-lived. Here, we show that protective immunity is prolonged by a sporozoite challenge after immunization. Repeated challenges induced sporozoite-specific antibodies that showed protective capacity. The numbers of CSP-specific CD8+ Tcells were not substantially enhanced by sporozoite infections; however, CSP-specific memory CD8+ Tcells of challenged mice displayed a higher cytotoxic activity than memory Tcells of immunized-only mice. CD4+ Tcells contributed to protection as w

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/GA310%2F08%2F0447" target="_blank" >GA310/08/0447: Mechanisms underlying modulation of immune cell functions by cAMP</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Immunology

ISSN

0014-2980

e-ISSN

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Volume of the periodical

43

Issue of the periodical within the volume

3

Country of publishing house

DE - GERMANY

Number of pages

12

Pages from-to

693-704

UT code for WoS article

000316140600015

EID of the result in the Scopus database

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