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Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F08%3A00315788" target="_blank" >RIV/61388971:_____/08:00315788 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid

  • Original language description

    Sterile immunity against malaria can be achieved by the induction of IFN?-producing CD8+ T cells that target infected hepatocytes presenting epitopes of the circumsporozoite protein (CSP). In the present study we evaluate the protective efficacy of a heterologous prime/boost immunization protocol based on the delivery of the CD8+ epitope of Plasmodium berghei CSP into the MHC class I presentation pathway, by either a type III secretion system of live recombinant Salmonella and/or by direct translocationof a recombinant Bordetella adenylate cyclase toxoid fusion (ACT-CSP) into the cytosol of professional antigen presenting cells (APCs). A single intraperitoneal application of the recombinant ACT-CSP toxoid, as well as a single oral immunization with the Salmonella vaccine, induced a specific CD8+ T cell response, which however conferred only a partial protection on mice against a subsequent sporozoite challenge

  • Czech name

    Prime/boost imunizační protokol antigenu CSP využívající sekreční systém typu III živé rekombinantní Salmonelly a rekombinantního ACT zajišťuje ochranou imunitu proti malarické infekci

  • Czech description

    Indukce specifické CTL buněčné odpovědi proti malarickému antigenu CSP zajišťuje ochranou imunitu proti malárii. V této práci jsme analyzovali roli prime/boost imunizačního protokolu v indukci CSP-zprostředkované ochranné imunity. Doprava CD8+ epitopu CSP do MHC-I dráhy antigenní prezentace pomocí rekombinantního ACT (ACT-CSP) anebo pomocí sekrečního systému typu III živé rekombinantní Salmonelly indukovala pouze částečnou ochranou imunitu. Avšak, použití prime/boost imunizačního protokolu vedlo k výraznému zvýšení CSP-specifických T buněk a kompletní protekci ve všech imunizovaných myších

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/2B06161" target="_blank" >2B06161: New tools for rapid and non-invasive diagnosing of latent infections.</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Vaccine

  • ISSN

    0264-410X

  • e-ISSN

  • Volume of the periodical

    26

  • Issue of the periodical within the volume

    47

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

  • UT code for WoS article

    000261750200008

  • EID of the result in the Scopus database