Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00379097" target="_blank" >RIV/61388971:_____/12:00379097 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/eji.201141955" target="_blank" >http://dx.doi.org/10.1002/eji.201141955</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/eji.201141955" target="_blank" >10.1002/eji.201141955</a>

Result language

angličtina

Original language name

Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration

Original language description

Malaria is still responsible for up to 1 million deaths per year worldwide, highlighting the need for protective malaria vaccines. Helminth infections that are prevalent in malaria endemic areas can modulate immune responses of the host. Here we show that Strongy-Ioides ratti, a gut-dwelling nematode that causes transient infections, did not change the efficacy of vaccination against Plasmodium berghei. An ongoing infection with Litomosoides sigmodontis, a tissue-dwelling filaria that induces chronic infections in BALB/c mice, significantly interfered with vaccination efficacy. The induction of P. berghei circumspor-ozoite protein (CSP)-specific CD8+ T cells, achieved by a single immunization with a CSP fusion protein, was diminished in L. sigmodontis-infected mice

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/GA310%2F08%2F0447" target="_blank" >GA310/08/0447: Mechanisms underlying modulation of immune cell functions by cAMP</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Immunology

ISSN

0014-2980

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

890-900

UT code for WoS article

000303157600012

EID of the result in the Scopus database

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