Target antigens for Hs-14 monoclonal antibody and their various expression in normozoospermic and asthenozoospermic men

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F15%3A00455664" target="_blank" >RIV/61388971:_____/15:00455664 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/15:00455664

Result on the web

<a href="http://link.springer.com/article/10.1186/s12610-015-0025-0" target="_blank" >http://link.springer.com/article/10.1186/s12610-015-0025-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12610-015-0025-0" target="_blank" >10.1186/s12610-015-0025-0</a>

Result language

angličtina

Original language name

Target antigens for Hs-14 monoclonal antibody and their various expression in normozoospermic and asthenozoospermic men

Original language description

Poor semen quality is one of the main causes of infertility. We have generated a set of monoclonal antibodies to human sperm and used them to investigate sperm quality. Some of these antibodies found differences in the expression of proteins between normal sperm and pathological sperm displaying severe defects. One of them was the Hs-14 antibody. The aim of this paper was to determine the target protein of the Hs-14 monoclonal antibody and to investigate the expression of the Hs-14-reacting protein on the sperm of asthenozoospermic men with sperm motility defect and of healthy normozoospermic men. The Hs-14 antibody binds fibronectin, ?-tubulin and valosin-containing protein - new name for this protein is transitional endoplasmic reticulum ATPase (TERA). Since the Hs-14 reaction with TERA remained the strongest at the highest antibody dilution, and Hs-14 consistently labelled the same spot or band as the monospecific anti-TERA antibody on immunoblots, we assume that TERA is an Hs-14-sp

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Basic and Clinical Andrology

ISSN

2051-4190

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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