Please do not recycle! Translation reinitiation in microbes and higher eukaryotes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F18%3A00488819" target="_blank" >RIV/61388971:_____/18:00488819 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/femsre/fux059" target="_blank" >http://dx.doi.org/10.1093/femsre/fux059</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/femsre/fux059" target="_blank" >10.1093/femsre/fux059</a>

Result language
angličtina
Original language name
Please do not recycle! Translation reinitiation in microbes and higher eukaryotes
Original language description
Protein production must be strictly controlled at its beginning and end to synthesize a polypeptide that faithfully copies genetic information carried in the encoding mRNA. In contrast to viruses and prokaryotes, the majority of mRNAs in eukaryotes contain only one coding sequence, resulting in production of a single protein. There are, however, many exceptional mRNAs that either carry short open reading frames upstream of the main coding sequence (uORFs) or even contain multiple long ORFs. A wide variety of mechanisms have evolved in microbes and higher eukaryotes to prevent recycling of some or all translational components upon termination of the first translated ORF in such mRNAs and thereby enable subsequent translation of the next uORF or downstream coding sequence. These specialized reinitiation mechanisms are often regulated to couple translation of the downstream ORF to various stimuli. Here we review all known instances of both short uORF-mediated and long ORF-mediated reinitiation and present our current understanding of the underlying molecular mechanisms of these intriguing modes of translational control.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/GA15-10116S" target="_blank" >GA15-10116S: Crossing the boundaries: analysis of functional mRNA elements determining the mechanism of translational reinitiation in lower and higher eukaryotes.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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