Low-carbohydrate diet in children and young people with type 1 diabetes: A randomized controlled trial with cross-over design
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F24%3A00599717" target="_blank" >RIV/61388971:_____/24:00599717 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/24:10484139 RIV/00216208:11320/24:10484139 RIV/60460709:41210/24:98799 RIV/00064203:_____/24:10484139
Result on the web
<a href="https://doi.org/10.1016/j.diabres.2024.111844" target="_blank" >https://doi.org/10.1016/j.diabres.2024.111844</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.diabres.2024.111844" target="_blank" >10.1016/j.diabres.2024.111844</a>
Alternative languages
Result language
angličtina
Original language name
Low-carbohydrate diet in children and young people with type 1 diabetes: A randomized controlled trial with cross-over design
Original language description
Aims: We investigated whether a short period of tightly controlled low-carbohydrate diet (LCD) leads to higher time in range without increasing the associated risks in children and young people with diabetes (CYPwD). Methods: Thirty-five (CYPwD) were recruited into this randomized controlled cross-over study (20 female, 20 CSII, age 14.5 f 2.9 years, HbA1c 48.9 f 9.4 mmol/mol). The interventions were five and five weeks of readymade food box deliveries of isocaloric diets in random order: either LCD (94.5 f 4.7 g/day) or recommended carbohydrate diet (RCD) (191 f 19.2 g/day). The outcomes were continuous glucose monitoring parameters, anthropometric, laboratory and quality of life (QoL) data. Results: Time in range was significantly higher in the LCD than in the RCD period (77.1 % vs. 73.8 %, P=0.008). Times in hyperglycemia and average glycaemia were significantly lower in the LCD. There was no difference between the diets in time in hypoglycemia or glycemic variability. The subjects' body weight and BMI were significantly lower during the LCD. There was no significant difference in the LDL-cholesterol levels. No significant differences were observed in the self-assessed QoL. Conclusions: Short-term LCD led to an improvement of glycemic parameters without increasing time in hypoglycemia, disturbing the lipid profile or negatively affecting the quality of life of CYPwD.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/NU21-01-00085" target="_blank" >NU21-01-00085: Low-carbohydrate diet in type 1 diabetes: effects on glycemic control and islet autoimmunity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetes Research and Clinical Practice
ISSN
0168-8227
e-ISSN
1872-8227
Volume of the periodical
217
Issue of the periodical within the volume
November
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
111844
UT code for WoS article
001311545700001
EID of the result in the Scopus database
2-s2.0-85203064321