Modelling the cardiac transverse-axial tubular system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F08%3A00087221" target="_blank" >RIV/61388998:_____/08:00087221 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/08:00024385 RIV/00216305:26220/08:PU71089
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Modelling the cardiac transverse-axial tubular system
Original language description
The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane iswithin the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is thecomplex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure?
Czech name
Modelování transverzálně-axiálního tubulárního systému u srdečních buněk
Czech description
Práce shrnuje nejnovější výsledky výpočtového modelování funkce transverzálně-axiálního tubulárního systému u srdečních komorových buněk a vytyčuje nové otázky ve výzkumu jeho fyziologické role.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Progress in Biophysics & Molecular Biology
ISSN
0079-6107
e-ISSN
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Volume of the periodical
96
Issue of the periodical within the volume
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Country of publishing house
GB - UNITED KINGDOM
Number of pages
18
Pages from-to
226-246
UT code for WoS article
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EID of the result in the Scopus database
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