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Magnetic poly(glycidyl methacrylate) microspheres for protein capture

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00430063" target="_blank" >RIV/61389013:_____/14:00430063 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.nbt.2014.06.004" target="_blank" >http://dx.doi.org/10.1016/j.nbt.2014.06.004</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.nbt.2014.06.004" target="_blank" >10.1016/j.nbt.2014.06.004</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Magnetic poly(glycidyl methacrylate) microspheres for protein capture

  • Original language description

    The efficient isolation and concentration of protein antigens from complex biological samples is a critical step in several analytical methods, such as mass spectrometry, flow cytometry and immunochemistry. These techniques take advantage of magnetic microspheres as immunosorbents. The focus of this study was on the development of new superparamagnetic polymer microspheres for the specific isolation of the tumor suppressor protein p53. Monodisperse macroporous poly(glycidyl methacrylate) (PGMA) microspheres measuring approximately 5 ?m and containing carboxyl groups were prepared by multistep swelling polymerization of glycidyl methacrylate (GMA), 2-[(methoxycarbonyl)methoxy]ethyl methacrylate (MCMEMA) and ethylene dimethylacrylate (EDMA) as a crosslinker in the presence of cyclohexyl acetate as a porogen. To render the microspheres magnetic, iron oxide was precipitated within their pores; the Fe content in the particles received 18 wt%. Nonspecific interactions between the magnetic pa

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CD - Macromolecular chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    New Biotechnology

  • ISSN

    1871-6784

  • e-ISSN

  • Volume of the periodical

    31

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    10

  • Pages from-to

    482-491

  • UT code for WoS article

    000341314700012

  • EID of the result in the Scopus database