The effect of ionizing radiation on biocompatible polymers: From sterilization to radiolysis and hydrogel formation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00469647" target="_blank" >RIV/61389013:_____/17:00469647 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.polymdegradstab.2017.01.005" target="_blank" >http://dx.doi.org/10.1016/j.polymdegradstab.2017.01.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.polymdegradstab.2017.01.005" target="_blank" >10.1016/j.polymdegradstab.2017.01.005</a>
Alternative languages
Result language
angličtina
Original language name
The effect of ionizing radiation on biocompatible polymers: From sterilization to radiolysis and hydrogel formation
Original language description
The sensitivity of biocompatible polymers to ionizing radiation plays a crucial role for the construction of polymer radiopharmaceutics, simultaneous radiotherapy and therapy with polymeric drugs, and the radiation sterilization of polymer samples. Herein, we answer the crucial but generally overlooked question of radiation stability of water-soluble biocompatible polymers that are used in designing of polymer radiotherapeutics. We ranked five different classes of widely used water-soluble polymers according to their sensitivity to the beta or gamma radiation, providing the guidelines for selection of appropriate polymers that will be in contact with radiation. As a result, poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) and poly(N-vinyl-2-pyrrolidone) (PVP) proved to be more resistant against ionizing radiation than poly(ethylene oxide) (PEO) or poly(2-ethyl-2-oxazoline) (PEtOx), which were crosslinked rapidly. Nevertheless, irradiation of PEtOx and PEO homopolymers appeared to be a fast and straightforward route to their respective hydrogels. Special emphasis was put on the beta radiation preparation of PEtOx hydrogels, which was never described before. Irradiation of poly(N-isopropyl acrylamide) (PNIPAM) in solution leads to its hydrophilization and an increase in its cloud point temperature.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymer Degradation and Stability
ISSN
0141-3910
e-ISSN
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Volume of the periodical
137
Issue of the periodical within the volume
March
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
1-10
UT code for WoS article
000396948100001
EID of the result in the Scopus database
2-s2.0-85009355997