Effect of Fe3O4@SiO2 nanoparticle diameter on glutamate transport in brain nerve terminals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00502417" target="_blank" >RIV/61389013:_____/19:00502417 - isvavai.cz</a>
Result on the web
<a href="https://www.ingentaconnect.com/content/asp/nnl/2019/00000011/00000001/art00008" target="_blank" >https://www.ingentaconnect.com/content/asp/nnl/2019/00000011/00000001/art00008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1166/nnl.2019.2853" target="_blank" >10.1166/nnl.2019.2853</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Fe3O4@SiO2 nanoparticle diameter on glutamate transport in brain nerve terminals
Original language description
Monodispersed silica-coated magnetite nanoparticles (Fe3O4 @ SiO2) with diameters of 11, 20, and 24 nm were synthesized by thermal decomposition, hydrolysis and condensation of tetramethyl orthosilicate. Substantial Fe3O4 @ SiO2 particle size effects on glutamate transport in brain nerve terminals were observed. The balance between tonic release and uptake of glutamate affects the extracellular glutamate concentration and physiological synaptic neurotransmission. A smaller particle diameter (11 nm) resulted in a greater extracellular concentration and tonic release of L-[14C]-glutamate in rat synaptosomes. However, lower L-[14C]-glutamate uptake and synaptic vesicle acidification was observed with larger particles (20 and 24 nm). The neuromodulatory effect of the Fe3O4 @ SiO2 nanoparticles in synaptosomes was considerably increased by decreasing the particle diameter from 24 to 11 nm. The particle diameter was determined to be a critical parameter, and the manipulation of this parameter could be used to control the effect of the nanoparticles in biotechnological and medical applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanoscience and Nanotechnology Letters
ISSN
1941-4900
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
61-69
UT code for WoS article
000459175700008
EID of the result in the Scopus database
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