Diphenylurea-derived cytokinin oxidase/dehydrogenase inhibitors for biotechnology and agriculture

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F21%3A00545687" target="_blank" >RIV/61389030:_____/21:00545687 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/21:73603659 RIV/60461373:22330/21:43922225

Result on the web

<a href="http://doi.org/10.1093/jxb/eraa437" target="_blank" >http://doi.org/10.1093/jxb/eraa437</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jxb/eraa437" target="_blank" >10.1093/jxb/eraa437</a>

Result language

angličtina

Original language name

Diphenylurea-derived cytokinin oxidase/dehydrogenase inhibitors for biotechnology and agriculture

Original language description

Increasing crop productivity is our major challenge if we are to meet global needs for food, fodder and fuel. Controlling the content of the plant hormone cytokinin is a method of improving plant productivity. Cytokinin oxidase/dehydrogenase (CKO/CKX) is a major target in this regard because it degrades cytokinins. Here, we describe the synthesis and biological activities of new CKX inhibitors derived mainly from diphenylurea. They were tested on four CKX isoforms from maize and Arabidopsis, where the best compounds showed IC50 values in the 10-8 M concentration range. The binding mode of the most efficient inhibitors was characterized from high-resolution crystal complexed structures. Although these compounds do not possess intrinsic cytokinin activity, we have demonstrated their tremendous potential for use in the plant tissue culture industry as well as in agriculture. We have identified a key substance, compound 19, which not only increases stress resistance and seed yield in Arabidopsis, but also improves the yield of wheat, barley and rapeseed grains under field conditions. Our findings reveal that modulation of cytokinin levels via CKX inhibition can positively affect plant growth, development and yield, and prove that CKX inhibitors can be an attractive target in plant biotechnology and agriculture.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Experimental Botany

ISSN

0022-0957

e-ISSN

1460-2431

Volume of the periodical

72

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

355-370

UT code for WoS article

000648886400016

EID of the result in the Scopus database

2-s2.0-85114672949