Beyond expectations: the development and biological activity of cytokinin oxidase/dehydrogenase inhibitors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F24%3A00603762" target="_blank" >RIV/61389030:_____/24:00603762 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1042/BST20231561" target="_blank" >https://doi.org/10.1042/BST20231561</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1042/BST20231561" target="_blank" >10.1042/BST20231561</a>

Result language

angličtina

Original language name

Beyond expectations: the development and biological activity of cytokinin oxidase/dehydrogenase inhibitors

Original language description

Cytokinins are one of the main groups of plant hormones that regulate growth and development of plants. Cytokinin oxidase/dehydrogenase (CKX) is an enzyme that rapidly and irreversibly degrades cytokinins and thus directly affects their concentration and physiological effect. Genetically modified plants with reduced CKX activity in the shoot, i.e. with a higher concentration of cytokinins, showed e.g. increased tolerance to drought stress, formed larger inflorescences and had higher grain yield. For these reasons, chemical compounds capable of inhibiting the CKX activity (CKX inhibitors) were sought. First, they were identified among strong synthetic cytokinins, but their inhibitory activity was low. The trend has been to develop potent CKX inhibitors with minimal intrinsic cytokinin activity in the hope of avoiding the negative effect of cytokinins on root growth. Cloning CKX, production of key recombinant enzymes from Arabidopsis (AtCKX2) and maize (ZmCKX1 and ZmCKX4a), development of screening bioassays and progress in X-ray crystallography and synthetic organic chemistry led to extensive progress in the development of these compounds. Currently, the most suitable CKX inhibitors are seeking their application in research and the commercial sphere in two main areas plant tissue cultures and agriculture. The key milestones that preceded it are summarized in this review.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemical Society Transactions

ISSN

0300-5127

e-ISSN

1470-8752

Volume of the periodical

52

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

2297-2306

UT code for WoS article

001391619700005

EID of the result in the Scopus database

2-s2.0-85213217052