Equine atypical myopathy: A metabolic study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33159246" target="_blank" >RIV/61989592:15110/16:33159246 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/16:43874170 RIV/00098892:_____/16:N0000019
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1090023316301125" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1090023316301125</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tvjl.2016.07.015" target="_blank" >10.1016/j.tvjl.2016.07.015</a>

Result language
angličtina
Original language name
Equine atypical myopathy: A metabolic study
Original language description
Atypical myopathy (AM) is a potentially fatal disease of grazing horses. It is reportedly caused by the ingestion of sycamore seeds containing toxic hypoglycin A. In order to study metabolic changes, serum and urine samples from nine horses with atypical myopathy and 12 control samples from clinically healthy horses were collected and then analysed using a high-performance liquid chromatography coupled with tandem mass spectrometry; serum metabolic profiles as the disease progressed were also studied. Metabolic data were evaluated using unsupervised and supervised multivariate analyses. Significant differences were demonstrated in the concentrations of various glycine conjugates and acylcarnitines (C2-C26). Moreover, the concentrations of purine and pyrimidine metabolites, vitamins and their degradation products (riboflavin, trigonelline, pyridoxate, pantothenate), and selected organic and amino acids (aspartate, leucine, 2-oxoglutarate, etc.) were altered in horses with AM. These results represent a global view of altered metabolism in horses with atypical myopathy.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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