Antigen Cross-Presentation and Heat Shock Protein-Based Vaccines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33162267" target="_blank" >RIV/61989592:15110/16:33162267 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs00005-015-0370-x" target="_blank" >http://link.springer.com/article/10.1007%2Fs00005-015-0370-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00005-015-0370-x" target="_blank" >10.1007/s00005-015-0370-x</a>
Alternative languages
Result language
angličtina
Original language name
Antigen Cross-Presentation and Heat Shock Protein-Based Vaccines
Original language description
Vaccines currently in the clinical use contain adjuvants stimulating preferably Th2 type of immune response associated with the production of specific antibodies, mostly of neutralizing isotypes. This kind of immune response is effective only against some types of pathogens and has limited effect against tumors and many viruses where parallel activation of antigen-specific humoral and cell-mediated immunity is required. One of the main objectives of the current vaccine research is the development of approaches leading to the induction of antigen-specific CD8? T cell response including cytotoxic T lymphocyte (CTL). Induction of antigen-specific CD8? T cell response to exogenously delivered antigen requires their cross-presentation by antigen presenting cells, especially dendritic cells. The cross-presentation principles seem to be crucial for effective activation of CTL. In this paper, we discuss some approaches to employing heat shock proteins for induction of antigen-specific CD8? T cells in the context of cross-presentation and cross-priming principles.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/EE2.3.20.0164" target="_blank" >EE2.3.20.0164: International research network</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archivum Immunologiae et Therapiae Experimentalis
ISSN
1661-4917
e-ISSN
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Volume of the periodical
64
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
1-18
UT code for WoS article
000368536300001
EID of the result in the Scopus database
2-s2.0-84954389632