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Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F05%3A00002284" target="_blank" >RIV/61989592:15310/05:00002284 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15110/05:00001927 RIV/61989592:15110/05:00002284

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine

  • Original language description

    Inhibition of porcine pancreas and human saliva alpha-amylase (EC 3.2. 1. 1) by sanguinarine and chelerythrine was studied. The inhibition of alpha-amylase was assayed using a biosensor method which utilises a flow system equipped with a peroxide electrode. 250 mu M sanguinarine and 250 mu M chelerythrine cause complete inhibition of 1.9 nkat alpha-amylase from porcine pancreas. The same concentration of sanguinarine and chelerythrine caused 23.9% and 7.5% inhibition, respectively, of 1.9 nkat alpha-amylase from human saliva. Mixed type and partially reversible inhibition was found for both alpha-amylases treated with either alkaloid.

  • Czech name

    Studium inhibice alfa-amylasy benzofenathridinovými alkaloidy sanguinarinem a chelerythrinem

  • Czech description

    Byla studována inhibice alfa-amylasy benzofenathridinovými alkaloidy sanguinarinem a chelerythrinem pomocí biosensoru. Látky vykazovaly inhibiční účinek vůči enzymu řádově při 0.1 mM koncentracích.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GP303%2F01%2FP085" target="_blank" >GP303/01/P085: Cytotoxicity of some phytopreparations and dietary supplements</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Enzyme Inhibition and Medicinal Chemistry

  • ISSN

    1475-6366

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    261-267

  • UT code for WoS article

  • EID of the result in the Scopus database