Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F05%3A00002284" target="_blank" >RIV/61989592:15310/05:00002284 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/05:00001927 RIV/61989592:15110/05:00002284
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine
Original language description
Inhibition of porcine pancreas and human saliva alpha-amylase (EC 3.2. 1. 1) by sanguinarine and chelerythrine was studied. The inhibition of alpha-amylase was assayed using a biosensor method which utilises a flow system equipped with a peroxide electrode. 250 mu M sanguinarine and 250 mu M chelerythrine cause complete inhibition of 1.9 nkat alpha-amylase from porcine pancreas. The same concentration of sanguinarine and chelerythrine caused 23.9% and 7.5% inhibition, respectively, of 1.9 nkat alpha-amylase from human saliva. Mixed type and partially reversible inhibition was found for both alpha-amylases treated with either alkaloid.
Czech name
Studium inhibice alfa-amylasy benzofenathridinovými alkaloidy sanguinarinem a chelerythrinem
Czech description
Byla studována inhibice alfa-amylasy benzofenathridinovými alkaloidy sanguinarinem a chelerythrinem pomocí biosensoru. Látky vykazovaly inhibiční účinek vůči enzymu řádově při 0.1 mM koncentracích.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP303%2F01%2FP085" target="_blank" >GP303/01/P085: Cytotoxicity of some phytopreparations and dietary supplements</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Enzyme Inhibition and Medicinal Chemistry
ISSN
1475-6366
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
261-267
UT code for WoS article
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EID of the result in the Scopus database
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