HRP-like activity og bare and modified magnetic nanoparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156631" target="_blank" >RIV/61989592:15310/15:33156631 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
HRP-like activity og bare and modified magnetic nanoparticles
Original language description
The horseradish peroxidase conjugated with antibody is used in many biochemical applications such as immunoassays or Western blots primarily for its ability to amplify a weak signal and increase detectability of a target molecules. Horseradish peroxidaseis susceptible to damage due to high/low temperatures, or by changing the pH. The magnetic particles exhibit the same behavior as horseradish peroxidase, and if a suitable substrate is used, this reaction could be detectable by spectrophotometer too. They catalyze the reaction in a broader range of temperature and pH compared to peroxidase. The catalytic reaction of magnetic nanoparticles is hydrogen peroxide dependent. Magnetic particles exhibit stronger peroxidase-like activity, but for practical applications it is necessary to modify the surface to ensure the specificity of binding to the target structure and also improve biocompatibility and stability. Magnetic nanoparticles modified with chitosan were compared with particles witho
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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