An electrochemical DNA-based biosensor to study the effects of CdTe quantum dots on UV-induced damage of DNA

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43907666" target="_blank" >RIV/62156489:43210/15:43907666 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/15:PU118492

Result on the web

<a href="http://link.springer.com/article/10.1007/s00604-015-1502-z/fulltext.html" target="_blank" >http://link.springer.com/article/10.1007/s00604-015-1502-z/fulltext.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00604-015-1502-z" target="_blank" >10.1007/s00604-015-1502-z</a>

Result language

angličtina

Original language name

An electrochemical DNA-based biosensor to study the effects of CdTe quantum dots on UV-induced damage of DNA

Original language description

A DNA-based biosensor is presented that can be applied to the detection of DNA damage caused by UV-C radiation (254 nm) in the presence of CdTe quantum dots (QDs). The sensor is composed of a glassy carbon electrode whose surface was modified with a layer of dsDNA and another layer of CdTe QDs. The response of this sensor is based on (a) the intrinsic anodic signal of the guanine moiety in the DNA that is measured by square-wave voltammetry, and (b) the cyclic voltammetric response of the redox indicator system hexacyanoferrate(III/II). Depending on the size of the QDs, they exert a significant effect on the rate of the degradation of dsDNA by UV-C light, and even by visible light. Time-dependent structural changes of DNA include opening of the doublehelix (as indicated by an increase in the redox response of the guanine moiety due to easy electron exchange with the electrode when compared to the original helix state and by an increase in the voltammetric peak current of the hexacyano

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

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Project

<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Microchimica Acta

ISSN

0026-3672

e-ISSN

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Volume of the periodical

182

Issue of the periodical within the volume

9-10

Country of publishing house

AT - AUSTRIA

Number of pages

8

Pages from-to

1715-1722

UT code for WoS article

000356449700017

EID of the result in the Scopus database

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