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Anticarcinogenic effect of spices due to phenolic and flavonoid compounds-in vitro evaluation on prostate cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F17%3A43912030" target="_blank" >RIV/62156489:43210/17:43912030 - isvavai.cz</a>

  • Alternative codes found

    RIV/62156489:43410/17:43912030

  • Result on the web

    <a href="https://doi.org/10.3390/molecules22101626" target="_blank" >https://doi.org/10.3390/molecules22101626</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/molecules22101626" target="_blank" >10.3390/molecules22101626</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Anticarcinogenic effect of spices due to phenolic and flavonoid compounds-in vitro evaluation on prostate cells

  • Original language description

    This study shows the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines (PNT1A, 22RV1 and PC3). The results of an MTT assay on extracts from eight spices revealed the strongest inhibitory effects were from black pepper and caraway seed extracts. The strongest inhibitory effect on prostatic cells was observed after the application of extracts of spices in concentration of 12.5 mg.mL- 1. An LC/MS analysis identified that the most abundant phenolic and flavonoid compounds in black pepper are 3,4-dihydroxybenzaldehyde and naringenin chalcone, while the most abundant phenolic and flavonoid compounds in caraway seeds are neochlorogenic acid and apigenin. Using an MTT assay for the phenolic and flavonoid compounds from spices, we identified the IC50 value of ~1 mmol.L- 1 PNT1A. The scratch test demonstrated that the most potent inhibitory effect on PNT1A, 22RV1 and PC3 cells is from the naringenin chalcone contained in black pepper. From the spectrum of compounds assessed, the naringenin chalcone contained in black pepper was identified as the most potent inhibitor of the growth of prostate cells.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

    <a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecules

  • ISSN

    1420-3049

  • e-ISSN

  • Volume of the periodical

    22

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    13

  • Pages from-to

    &quot;nestrankovano&quot;

  • UT code for WoS article

    000414670600054

  • EID of the result in the Scopus database

    2-s2.0-85030785430