Theranostic Approach for the Protein Corona of Polysaccharide Nanoparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F21%3A43918781" target="_blank" >RIV/62156489:43210/21:43918781 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43510/21:43918781
Result on the web
<a href="https://doi.org/10.1002/tcr.202000042" target="_blank" >https://doi.org/10.1002/tcr.202000042</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/tcr.202000042" target="_blank" >10.1002/tcr.202000042</a>

Result language
angličtina
Original language name
Theranostic Approach for the Protein Corona of Polysaccharide Nanoparticles
Original language description
Polysaccharide nanoparticles are promising materials in the wide range of disciplines such as medicine, nutrition, food production, agriculture, material science and others. They excel not only in their non-toxicity and biodegradability but also in their easy preparation. As well as inorganic particles, a protein corona (PC) around polysaccharide nanoparticles is formed in biofluids. Moreover, it has been considered that the overall response of the organism to nanoparticles presence depends on the PC. This review summarises scientific publications about the structural chemistry of polysaccharide nanoparticles and their impact on theranostic applications. Three strategies of implementation of the PC in theranostics have been discussed: I) Utilisation of the PC in therapy; II) How the composition of the PC is analysed for specific disease markers; III) How the formed PC can interact with the immune system and enhances the immunomodulation or immunoelimination. Thus, the findings from this review can contribute to improve the design of drug delivery systems. However, it is still necessary to elucidate the mechanisms of nano-bio interactions and discover new connections in nanoscale research.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology

Project
<a href="/en/project/LTC18002" target="_blank" >LTC18002: The development of new materials suitabled for 3D printing with antimicrobial properties (3D ANTIMICROB)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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