Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870661" target="_blank" >RIV/62157124:16370/11:43870661 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.intimp.2011.02.016" target="_blank" >http://dx.doi.org/10.1016/j.intimp.2011.02.016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.intimp.2011.02.016" target="_blank" >10.1016/j.intimp.2011.02.016</a>
Alternative languages
Result language
angličtina
Original language name
Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells
Original language description
The cytotoxicity and in vitro effects of six variously modified types of cellulose (OC - oxidized cellulose, NaOC - oxidized cellulose sodium salt, DAC - dialdehyde cellulose, CMC - carboxymethyl cellulose, MFC - microfibrilated cellulose, and MCC - microcrystalline cellulose) on the inflammatory response in macrophage-like THP-1 cells were examined, with special focus on their ability to influence gene expression and the production of TNF-alpha. The study provides evidence that DAC exerts a marked effect on the induction of TNF-alpha gene expression and its subsequent production in human macrophages. Thus, the use of DAC for anti-hemorrhagic or wound-healing therapy should be considered carefully with regard to its pro-inflammatory activity. On the contrary, MCC showed significant anti-inflammatory effects in the LPS-induced conditions, which might be beneficial for the treatment of non-healing chronic wounds, e.g., diabetic or venous ulcers.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/2A-1TP1%2F073" target="_blank" >2A-1TP1/073: *New pharmaceutical products based on polysaccharides</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INTERNATIONAL IMMUNOPHARMACOLOGY
ISSN
1567-5769
e-ISSN
—
Volume of the periodical
11
Issue of the periodical within the volume
8
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
997-1001
UT code for WoS article
000293723400014
EID of the result in the Scopus database
—