Chromatographic behaviour predicts the ability of potential nootropics to permeate the blood-brain barrier.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872326" target="_blank" >RIV/62157124:16370/13:43872326 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3797/scipharm.1208-19" target="_blank" >http://dx.doi.org/10.3797/scipharm.1208-19</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3797/scipharm.1208-19" target="_blank" >10.3797/scipharm.1208-19</a>

Result language

angličtina

Original language name

Chromatographic behaviour predicts the ability of potential nootropics to permeate the blood-brain barrier.

Original language description

The log BB parameter is the logarithm of the ratio of a compound's equilibrium concentrations in the brain tissue versus the blood plasma. This parameter is a useful descriptor in assessing the ability of a compound to permeate the blood-brain barrier. The aim of this study was to develop a Hansch-type linear regression QSAR model that correlates the parameter log BB and the retention time of drugs and other organic compounds on a reversed-phase HPLC containing an embedded amide moiety. The retention time was expressed by the capacity factor log k'. The second aim was to estimate the brain's absorption of 2-(azacycloalkyl)acetamidophenoxyacetic acids, which are analogues of piracetam, nefiracetam, and meclofenoxate. Notably, these acids may be novel nootropics. Two simple regression models that relate log BB and log k' were developed from an assay performed using a reversed-phase HPLC that contained an embedded amide moiety. Both the quadratic and linear models yielded statistical para

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientia Pharmaceutica

ISSN

0036-8709

e-ISSN

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Volume of the periodical

81

Issue of the periodical within the volume

1

Country of publishing house

AT - AUSTRIA

Number of pages

11

Pages from-to

81-91

UT code for WoS article

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EID of the result in the Scopus database

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