Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873204" target="_blank" >RIV/62157124:16370/14:43873204 - isvavai.cz</a>
Result on the web
<a href="http://www.pub.iapchem.org/ojs/index.php/admet/article/download/155/pdf" target="_blank" >http://www.pub.iapchem.org/ojs/index.php/admet/article/download/155/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5599/admet.2.4.155" target="_blank" >10.5599/admet.2.4.155</a>
Alternative languages
Result language
angličtina
Original language name
Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers
Original language description
The investigation deals with the influence of permeation of rutin from carboxymethyl cellulose gel through full-thickness pig ear skin by (S)- and (R)-alaptide as potential excipients. Alaptide, 8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. By means of this rapid screening it was found out that the permeation of rutin through the skin increased linearly with time and was enhanced by both enantiomers of alaptide: approx. 1.2-fold by (R)-alaptide and approx. 1.5-fold by (S)-alaptide
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
O - Projekt operacniho programu
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ADMET & DMPK
ISSN
1848-7718
e-ISSN
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Volume of the periodical
2
Issue of the periodical within the volume
4
Country of publishing house
HR - CROATIA
Number of pages
6
Pages from-to
248-253
UT code for WoS article
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EID of the result in the Scopus database
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