LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00469444" target="_blank" >RIV/67985823:_____/16:00469444 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10329127 RIV/00064165:_____/16:10329127
Result on the web
<a href="http://dx.doi.org/10.18632/oncotarget.9959" target="_blank" >http://dx.doi.org/10.18632/oncotarget.9959</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18632/oncotarget.9959" target="_blank" >10.18632/oncotarget.9959</a>
Alternative languages
Result language
angličtina
Original language name
LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis
Original language description
p53 is a major cellular tumor suppressor that in addition to its nuclear, transcription-dependent activity is also known to function extranuclearly. Cellular stressors such as reactive oxygen species can promote translocation of p53 into mitochondria where it acts to protect mitochondrial genome or trigger cell death via transcription-independent manner. Here we report that the mammalian homologue of yeast mitochondrial Afg1 ATPase (LACE1) promotes translocation of p53 into mitochondria. We further show that LACE1 exhibits significant pro-apoptotic activity, which is dependent on p53, and that the protein is required for normal mitochondrial respiratory function. LACE1 physically interacts with p53 and is necessary for mitomycin c-induced translocation of p53 into mitochondria. Conversely, increased expression of LACE1 partitions p53 to mitochondria, causes reduction in nuclear p53 content and induces apoptosis. Thus, LACE1 mediates mitochondrial translocation of p53 and its transcription-independent apoptosis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GA13-07223S" target="_blank" >GA13-07223S: Function of human ClpXP protease and LACE1 ATPase in mitochondrial biogenesis and protein homeostasis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
OncoTarget
ISSN
1949-2553
e-ISSN
—
Volume of the periodical
7
Issue of the periodical within the volume
30
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
47687-47698
UT code for WoS article
000385413000067
EID of the result in the Scopus database
2-s2.0-84982836612