Ribonucleases, nucleases and antiangiogenins in antiproliferative activities

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F11%3A00373351" target="_blank" >RIV/67985904:_____/11:00373351 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2174/157436211797483921" target="_blank" >http://dx.doi.org/10.2174/157436211797483921</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/157436211797483921" target="_blank" >10.2174/157436211797483921</a>

Result language
angličtina
Original language name
Ribonucleases, nucleases and antiangiogenins in antiproliferative activities
Original language description
The animal ribonucleases and plant nucleases are selective cytotoxic enzymes with several biological activities inclusively also with antitumorous effects. The first attention from animal researches is dated to 1938 year, meanwhile plant enzyme investigators awoke their attention in last time. The bovine pancreatic ribonuclease, after the first structurally studies, allured very soon the peoples with functionally interests. The results of studies directed to antitumor effect were firstly very weak. Thelatter isolated bovine seminal ribonuclease was more effective from this aspect. Also human pancreatic ribonuclease stimulated interest about its antitumor activity what was realized by its dimerization and other molecular studies. Ribonuclease inhibitors have been very limited substances in the cytotoxicity of antitumor effectivity. On the other side a conjugation of cytostatic enzymes with polymers enhanced the antitumor activity of them and lowered their toxicity.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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