DNA interactions of monofuntional organometallic ruthenium(II) antitumor complexes in cell-free media.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F03%3A17033053" target="_blank" >RIV/68081707:_____/03:17033053 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

DNA interactions of monofuntional organometallic ruthenium(II) antitumor complexes in cell-free media.

Original language description

Modifications of natural DNA in a cell-free medium by antitumor monodentate Ru(II) arene compounds of the general formula [(&#61544;6-arene)Ru(en)Cl]+ (arene = biphenyl, dihydroanthracene, tetrahydroanthracene, p-cymene, or benzene; en = ethylenediamine)were studied. The results indicate that these complexes bind preferentially to guanine residues in double-helical DNA. The data are consistent with DNA binding of the complexes containing biphenyl, dihydroanthracene, or tetrahydroanthracene ligands thatinvolves combined coordination to G N7 and noncovalent interactions between the arene ligand and DNA. The single hydrocarbon rings in the p-cymene and benzene ruthenium complexes cannot interact with DNA by intercalation. It has been suggested that thedifferent character of conformational alterations induced in DNA may affect differently further downstream effects of damaged DNA and may result in different biological effects of this new class of antitumor compounds.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemistry

ISSN

0006-2960

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

39

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

11544-11554

UT code for WoS article

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EID of the result in the Scopus database

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