Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F10%3A00342523" target="_blank" >RIV/68081707:_____/10:00342523 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17310/10:A1100XUE
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs
Original language description
Selective binding of p53 to negatively and positively supercoiled DNA was studied using intercalative drugs chloroquine, ethidium bromide, acridine derivatives and doxorubicin as a modulators of the level of DNA supercoiling. The p53 was found to lose gradually its preferential binding to negatively scDNA with increasing concentrations of intercalators until the DNA negative superhelix turns were relaxed. Formation of positive superhelices rendered the circular duplex DNA to be preferentially bound by the p53 again.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)