Voltammetric behavior of a candidate anticancer drug roscovitine at carbon electrodes in aqueous buffers and a cell culture medium

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00504503" target="_blank" >RIV/68081707:_____/19:00504503 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/19:00108147

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs00706-018-2333-5" target="_blank" >https://link.springer.com/article/10.1007%2Fs00706-018-2333-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-018-2333-5" target="_blank" >10.1007/s00706-018-2333-5</a>

Result language

angličtina

Original language name

Voltammetric behavior of a candidate anticancer drug roscovitine at carbon electrodes in aqueous buffers and a cell culture medium

Original language description

Roscovitine is a candidate anticancer drug acting as an inhibitor of cyclin-dependent kinases which are involved in cell-cycle control and in apoptosis triggering. In our present study,we show for the first time that roscovitine yields a well-developed, analytically useful signal due to its irreversible electrochemical oxidation in alkaline range of pH (while in acidic media, its oxidation process is apparently rather complex and corresponding voltammetric signals are less suitable for analytical purposes). We demonstrate the possibility of voltammetric determination of the drug in buffer solutions (down to submicromolar concentrations of roscovitine) as well as in cell culture medium (down to micromolar concentrations) using in-house-fabricated pyrolytic graphite or screen-printed carbon electrodes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10406 - Analytical chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Monatshefte fur Chemie

ISSN

0026-9247

e-ISSN

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Volume of the periodical

150

Issue of the periodical within the volume

3

Country of publishing house

AT - AUSTRIA

Number of pages

7

Pages from-to

461-467

UT code for WoS article

000461394400013

EID of the result in the Scopus database

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