Macrophages and Toxicity of Nanomaterials: a mini-review

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00476180" target="_blank" >RIV/68378041:_____/16:00476180 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Macrophages and Toxicity of Nanomaterials: a mini-review
Original language description
Nanomaterials (NM) and nanotechnologies have a potential to revolutionize many aspects of human life, including medicine, personal care, energy production, and environmental protection. For a safe and sustainable use of any new technology, possible adverse health effects should be investigated alongside with the technology development. Unique NM properties that are desirable in novel applications may give rise to unexpected toxicities. From the perspective of the immune system, NM represent invading agents. Macrophages, as the first-line defense against foreign objects that entered the body, are tasked (i) to recognize if these objects (e.g. NM) might pose a theat to the organism, (ii)to trigger appropriate reactions. The recognition of NM by macrophages and subsequent NM-macrophages interactions can therefore determine the fate of the NM as well as their potential toxic effects. The present chapter focuses on ways by which NM disrupt or excessively activate macrophage functions and they will be discussed in the context of potential pathological consequences.
Czech name
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Czech description
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Project
<a href="/en/project/LO1508" target="_blank" >LO1508: Genomics and proteomics in the study of mechanisms of biological effects of produced nanoparticles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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