Melanocytes and Pigmentation in Tissue Engineering
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00490702" target="_blank" >RIV/68378041:_____/17:00490702 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Melanocytes and Pigmentation in Tissue Engineering
Original language description
Skin is the largest organ of human body, representing a functional barrier against the external environment. In case of injury, the barrier function is disrupted and human body becomes vulnerable. Skin tissue engineering focuses on restoration of skin using proper stimuli. However, natural-looking pigmentation remains an issue. The aim of this study was to investigate the effect of growth factors on melanocyte proliferation and melanin synthesis. Epidermal growth factor, hepatocyte growth factor and platelet-derived growth factor-AA were added to cell culture media at concentrations of 0 ng/mL to 40 ng/mL, and their effect on melanocytes was assessed. The data did not show any statistically significant effect on melanocyte proliferation. However, in melanin synthesis, pronounced dose-dependent effect was observed, with hepatocyte growth factor stimulating melanin synthesis in lower concentrations and platelet-derived growth factor AA in higher concentrations. These findings indicate suitability of growth factors for stimulation of pigmentation in tissue engineering.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Result continuities
Project
<a href="/en/project/LO1508" target="_blank" >LO1508: Genomics and proteomics in the study of mechanisms of biological effects of produced nanoparticles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Nanomaterials in Biomedical research
ISBN
978-80-906655-5-2
Number of pages of the result
5
Pages from-to
40-44
Number of pages of the book
140
Publisher name
Proxima Tisk, s.r.o.
Place of publication
Praha 3
UT code for WoS chapter
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