Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455742" target="_blank" >RIV/68378050:_____/15:00455742 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.devcel.2015.11.025" target="_blank" >http://dx.doi.org/10.1016/j.devcel.2015.11.025</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.devcel.2015.11.025" target="_blank" >10.1016/j.devcel.2015.11.025</a>

Result language

angličtina

Original language name

Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis

Original language description

The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of theorgan primordium. By combining lineage tracing, genetic cell ablation, and confocal live imaging, we identified a migratory population of Fgf8-expressing epithelial cells in the embryonic mandible. These Fgf8-expressing progenitors furnish the epithelial cells required for tooth development, and the progenitor population migrates toward a Shh-expressing region in the mandible, where the tooth placode will initiate. Inhibition of Fgf and Shh signaling disrupted the oriented migration of cells, leading to a failure of tooth development. These results demonstrate the importance of intraepithelial cell migration in proper positioning of an initiating organ.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/ED1.1.00%2F02.0109" target="_blank" >ED1.1.00/02.0109: Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Developmental Cell

ISSN

1534-5807

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

713-724

UT code for WoS article

000366946000011

EID of the result in the Scopus database

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