The actin regulator profilin 1 is functionally associated with the mammalian centrosome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F20%3A00540121" target="_blank" >RIV/68378050:_____/20:00540121 - isvavai.cz</a>
Result on the web
<a href="https://www.life-science-alliance.org/content/4/1/e202000655" target="_blank" >https://www.life-science-alliance.org/content/4/1/e202000655</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.26508/lsa.202000655" target="_blank" >10.26508/lsa.202000655</a>

Result language
angličtina
Original language name
The actin regulator profilin 1 is functionally associated with the mammalian centrosome
Original language description
Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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