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The actin regulator profilin 1 is functionally associated with the mammalian centrosome

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00540121" target="_blank" >RIV/68378050:_____/21:00540121 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.life-science-alliance.org/content/4/1/e202000655" target="_blank" >https://www.life-science-alliance.org/content/4/1/e202000655</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.26508/lsa.202000655" target="_blank" >10.26508/lsa.202000655</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The actin regulator profilin 1 is functionally associated with the mammalian centrosome

  • Original language description

    Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Life Science Alliance

  • ISSN

    2575-1077

  • e-ISSN

    2575-1077

  • Volume of the periodical

    4

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    e202000655

  • UT code for WoS article

    000614606300003

  • EID of the result in the Scopus database