The actin regulator profilin 1 is functionally associated with the mammalian centrosome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00540121" target="_blank" >RIV/68378050:_____/21:00540121 - isvavai.cz</a>
Result on the web
<a href="https://www.life-science-alliance.org/content/4/1/e202000655" target="_blank" >https://www.life-science-alliance.org/content/4/1/e202000655</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.26508/lsa.202000655" target="_blank" >10.26508/lsa.202000655</a>
Alternative languages
Result language
angličtina
Original language name
The actin regulator profilin 1 is functionally associated with the mammalian centrosome
Original language description
Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Life Science Alliance
ISSN
2575-1077
e-ISSN
2575-1077
Volume of the periodical
4
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
e202000655
UT code for WoS article
000614606300003
EID of the result in the Scopus database
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