A novel Cu(II)-based DNA-intercalating agent: Structural and biological insights using biophysical and in silico techniques
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00570899" target="_blank" >RIV/68378271:_____/23:00570899 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.saa.2023.122438" target="_blank" >https://doi.org/10.1016/j.saa.2023.122438</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.saa.2023.122438" target="_blank" >10.1016/j.saa.2023.122438</a>
Alternative languages
Result language
angličtina
Original language name
A novel Cu(II)-based DNA-intercalating agent: Structural and biological insights using biophysical and in silico techniques
Original language description
A new mixed-ligand Cu(II) complex formulated as [Cu(dipic)(amp)(H2O)].H2O (dipic: pyridine-2,6-dicarboxylic acid, amp: 2-amino-4-methylpyridine), was synthesized and structurally characterized by FTIR spectroscopy, CHN analysis, and the single-crystal X-ray crystallographic method. In order to systematically explore a detailed in vitro and in silico study of the DNA binding of the title complex, various biophysical (UV–Vis absorption spectroscopy, fluorescence, competitive binding with ethidium bromide) and theoretical (DFT, molecular docking simulation, and QM/MM) methods were applied.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy
ISSN
1386-1425
e-ISSN
1873-3557
Volume of the periodical
293
Issue of the periodical within the volume
May
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
16
Pages from-to
122438
UT code for WoS article
001005375400001
EID of the result in the Scopus database
2-s2.0-85147538847