Robustness of Time-Multiplexed Hyperthermia to Temperature Dependent Thermal Tissue Properties

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F20%3A00341614" target="_blank" >RIV/68407700:21460/20:00341614 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1109/JERM.2019.2959710" target="_blank" >https://doi.org/10.1109/JERM.2019.2959710</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/JERM.2019.2959710" target="_blank" >10.1109/JERM.2019.2959710</a>

Result language

angličtina

Original language name

Robustness of Time-Multiplexed Hyperthermia to Temperature Dependent Thermal Tissue Properties

Original language description

Microwave hyperthermia is a promising cancer treatment used in combination with radio- and chemotherapy. Typically, hyperthermia systems involve several antennas that transfer electromagnetic energy into the tissue. The principal need in hyperthermia treatment is to optimally focus the heating into the target while minimising heating in the surrounding healthy tissue. Patient-specific treatment planning is done to optimize the specific absorption rate and the resulting temperature distribution. Uncertainties associated with the thermal model used for temperature simulations represent an important challenge. Our previous work has demonstrated that the occurrence of hotspots can be reduced and target heating enhanced using time-multiplexed steering procedures. In this paper, the robustness of time-multiplexed hyperthermia against temperature dependent thermal tissue properties is investigated. Temperature simulations are used to predict the time-dependent heating achieved by multiple antenna phase and amplitude configurations that are generated by a multi-objective genetic algorithm and applied sequentially. The proposed strategy is compared with the heating obtained using one single heating setting obtained by particle swarm optimization as typically used in clinical hyperthermia. Thermal performance of the static and time-multiplexed methods are assessed by applying two thermal models, one that uses constant properties of blood perfusion and thermal conductivity of tumor, muscle and fat, and a second one that uses temperature dependent perfusion values. This study shows that time-multiplexed hyperthermia enhances target heating and limits the hotspot appearance regardless of the thermal model used in thermal simulations.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

20201 - Electrical and electronic engineering

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology

ISSN

2469-7249

e-ISSN

—

Volume of the periodical

4

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

126-132

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85076852869