The determination of water soluble vitramins in multivitamin pharmaceutical preparations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F10%3A63509394" target="_blank" >RIV/70883521:28110/10:63509394 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The determination of water soluble vitramins in multivitamin pharmaceutical preparations
Original language description
A rapid, simple and reliable liquid chromatographic method has been developed for the determination of thiamin, nicotinamide, panthothenic acid and pyridoxine in pharmaceutical preparations. HPLC equipped with a reversed?phase C8 was used. A mobile phaseof methanol-phosphate buffer (10:90, v/v) and a flow rate of 0.8 ml.min-1 gave the most satisfactory separation of those vitamins using a UV detector set up at 204 nm and 220 nm. Detection limits ranged from 2.0 to 12.0 ?g.ml-1. When the method was applied to the determination of the vitamins, the found values were lower or close with those on the labels. The differences in the tablet contents of vitamins may be influenced by the kind of pharmaceutical preparation, by technical preparation making process and by the storage conditions.
Czech name
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Czech description
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Bezpečnosť a kontrola potravín (Zborník prác z medzinárodnej vedeckej konferencie)
ISBN
978-80-552-0350-8
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
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Publisher name
Slovenská poľnohospodárská univerzita v Nitre
Place of publication
Nitra
Event location
Nitra
Event date
Jan 1, 2010
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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